Phenergan syrup pediatric dose

Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-desmethylpromethazine are the predominant metabolites appearing in the urine. Because promethazine causes pronounced sedation, an enhanced CNS depressant effect or additive drowsiness may occur when it is combined with other CNS depressants including sedating H1-blockers. In addition, co-administration of bupropion with medications that are metabolized by the CYP2D6 isoenzyme, such as promethazine, should be approached with caution. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include sorafenib. Co-administration of promethazine with loxapine may increase the risk of adverse effects such as drowsiness, phenergan anxiety dizziness, orthostatic hypotension, anticholinergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, or seizures. Brompheniramine; Guaifenesin; Hydrocodone: (Moderate) Additive anticholinergic effects may be seen when promethazine is used concomitantly with other drugs with antimuscarinic activity like sedating H1-blockers. If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA. Additionally, at high concentrations, gefitinib is an inhibitor of CYP2D6, which is the primary isoenzyme responsible for the metabolism of promethazine. Ethanol: (Major) Patients should generally be counseled to avoid alcohol use during phenothiazine therapy, due to additive central nervous system (CNS) depression and the potential to increase psychomotor impairment. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc generic desyrel interval in rare instances. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with promethazine include mifepristone, RU-486. Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate: (Major) Promethazine carries a possible risk of QT prolongation. Cobicistat: (Moderate) Caution is warranted when cobicistat is administered with promethazine as there is a potential for phenergan zolpidem elevated promethazine and phenergan syrup pediatric dose cobicistat concentrations. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with primaquine include promethazine. (Minor) Plasma concentrations of dextromethorphan may be elevated when administered concurrently with cobicistat. Clinicians should note that antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation. Because promethazine is a phenothiazine, the risk of drowsiness, dizziness, hypotension, extrapyramidal symptoms, anticholinergic effects, neuroleptic malignant syndrome, or seizures may be phenergan syrup pediatric dose increased during combined use. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. If serotonin syndrome occurs, all serotonergic agents should be discontinued and appropriate medical treatment should be implemented. If serotonin syndrome occurs, all serotonergic agents should how to administer valium and phenergan be discontinued and appropriate medical treatment should be implemented. If no acceptable alternative therapy is available, perform a baseline ECG prior to initiation of concomitant therapy and carefully follow monitoring recommendations. Due to the risk of additive QT prolongation and potential for serious arrhythmias, avoid co-use with quetiapine if possible. Brompheniramine; Carbetapentane; Phenylephrine: (Moderate) Additive anticholinergic effects may be seen when promethazine is used concomitantly with other drugs with antimuscarinic activity like sedating H1-blockers. Serious CNS reactions, such as serotonin syndrome, have been reported during the concurrent use of linezolid and psychiatric medications that enhance central serotonergic activity; therefore, caution is warranted with concomitant use of other agents with serotonergic activity, including dextromethorphan. Clinicians should note that antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation. Ziprasidone has been associated with a possible risk for QT prolongation and/or torsades de pointes. An enhanced CNS depressant effect may occur when carbetapentane is combined with other CNS depressants including promethazine. During one in vivo study, co-administration of dextromethorphan and clobazam resulted in increased AUC and Cmax of dextromethorphan by 90% and 59%, respectively. Anticholinergics: (Moderate) Additive anticholinergic effects may be seen provigil canada when anticholinergics are used concomitantly provigil coupon cvs with phenothiazines, including promethazine. Dronabinol, THC: (Moderate) Concomitant use of dronabinol with promethazine can potentiate the effects of dronabinol on respiratory depression. Patients taking antidiabetic agents should be closely monitored for worsening glycemic control when a phenothiazine is instituted. Carbetapentane; Phenylephrine; Pyrilamine: (Moderate) Drowsiness has been reported during administration of drugs containing carbetapentane. Because manufacturers are constantly revising the ingredients of cough and cold formulas on the market, the patient should carefully assess product labels for the presence of dextromethorphan as phenergan dm codeine an ingredient prior to any such product use. Atazanavir; Cobicistat: (Moderate) Caution is warranted when cobicistat is administered with promethazine as there is a potential for elevated promethazine and cobicistat concentrations.