Phenergan with codeine action
• Do not give Promethazine Hydrochloride and Codeine Phosphate Oral Solution to children younger than 12 years of age. To make sure Phenergan is safe for you, tell your doctor if you have: • asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder; • a sulfite allergy; • a history of seizures; • a weak immune system (bone marrow depression); • glaucoma; • enlarged prostate or problems with urination; • stomach ulcer or obstruction; • heart disease or high blood pressure; • liver disease; • adrenal gland tumor (pheochromocytoma); • low levels of calcium in your blood (hypocalcemia); or • if you have ever had a serious side effect while using promethazine or any other phenothiazine. Genitourinary: Oliguria, urinary retention, antidiuretic effect has been reported (common to narcotic analgesics). See the end of this Medication Guide for a complete list of ingredients in Promethazine Hydrochloride and Codeine Phosphate Syrup. Antihistamines and codeine are both contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma. Active ingredients: promethazine hydrochloride and codeine phosphate Inactive ingredients: Anhydrous Citric Acid, Ascorbic Acid, D & C Red # 33, Edetate Disodium, Glycerin, Methylparaben, Natural and Artificial Banana Flavor FN-6713, Natural and Artificial Fruit Flavor FN-6714, Purified Water, Saccharin Sodium, Sodium Benzoate, Sodium Citrate desyrel common side effects and Sucrose. Leukopenia and phenergan with codeine action agranulocytosis have been reported, usually when promethazine hydrochloride has been used anti nausea medication phenergan in association with other known marrow-toxic agents. • Promethazine Hydrochloride and Codeine Phosphate Syrup can cause breathing problems (respiratory depression) and drowsiness. • Head Injury and Increased Intracranial Pressure The respiratory-depressant effects of narcotic analgesics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, intracranial lesions, or a pre-existing increase in intracranial pressure. Because of phenergan 25mg how to take this risk, patients should avoid concomitant use of Promethazine HCl and Codeine Phosphate Oral Solution with benzodiazepines or other CNS depressants, including alcohol (See ). These doses are from approximately 2. Ambulatory patients should be told to avoid engaging in such activities until it is known that they do not become drowsy or dizzy from Promethazine and Codeine therapy. Furthermore, children with obstructive sleep apnea who are treated with codeine for post-tonsillectomy and/or adenoidectomy pain may be particularly sensitive to its respiratory depressant effect. Tell your healthcare provider if you have ever abused or been dependent on alcohol, prescription medicines or street drugs • Promethazine phenergan with codeine action Hydrochloride and Codeine Phosphate Oral Solution is not for children under 12 years of age. 2 times the maximum recommended total daily dose of promethazine for a 50-kg subject depending upon the indication for desyrel 50 mg 30 tablet endikasyonlar which the drug is prescribed. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis and extensor-plantar reflexes (Babinski reflex). Respiratory: Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal) (see ). Monoamine Oxidase Inhibitors (MAOI): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Paradoxical Reactions: Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. • Do not give Promethazine Hydrochloride and Codeine Phosphate Oral Solution to children younger than 12 years of age, or to children younger than 18 years of age after tonsillectomy or adenoidectomy surgery. Promethazine HCl and Codeine Phosphate Oral Solution is contraindicated for postoperative management in children younger than 18 years who have undergone tonsillectomy and/or adenoidectomy. If the mother has received narcotic analgesics during labor, newborn infants should be observed closely for signs of respiratory depression. It is used in preference to morphine, because side effects are nuvigil provigil cost infrequent at the usual antitussive dose of codeine. 1 to 4. • Convulsions Convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. Codeine is metabolized primarily in the liver by enzymes of the endoplasmic reticulum, where it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid. Drug Abuse and Dependence Controlled Substance Promethazine hydrochloride and codeine phosphate syrup is a side effects of phenergan dm Schedule V Controlled Substance. • Do not take more than 30 mL of Promethazine Hydrochloride and Codeine Phosphate Oral Solution in 24 hours. Sedation, somnolence, blurred vision, dizziness, confusion, disorientation and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Concomitant Conditions and Other Risk Factors Avoid use of promethazine in patients at risk for respiratory depression. In another study a single 100-mg/kg dose of codeine administered to pregnant mice reportedly resulted in delayed ossification in the offspring. Promethazine and Respiratory Depression in Children Postmarketing cases of respiratory depression, including fatalities have been reported with use of promethazine in pediatric patients. See also: Phenergan dosing information Usual Adult Dose for Anaphylaxis: Parenteral: 25 mg IV or IM once, followed by close observation for response. Respiratory depression, nightmares, delirium and agitated behavior have also been reported in some of these patients. Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. Most of the reported cases occurred following tonsillectomy and/or adenoidectomy, and many of the children had evidence of being an ultra-rapid metabolizer of codeine due to a CYP2D6 polymorphism.